· 

人工智能

 

·

Claude 3发布，全方位优于GPT-4

Claude 3模型系列与其他模型的比较（图片来源：Anthropic）

当地时间3月4日，由OpenAI前成员创立的人工智能（AI）公司Anthropic发布了Claude 3模型系列

，共包括3个模型，按智能水平和成本由低到高依次为Claude 3 Haiku、Claude 3 Sonnet和Claude 3 Opus。Anthropic表示，Opus模型在本科生水平专家知识（MMLU）、研究生水平专家推理（GPQA）和基础数学（GSM8K）等方面均优于GPT-4，在复杂任务上表现出接近人类水平的理解力和连贯性。目前，Claude 3系列提供200K的上下文窗口，接受超过100万token的输入，可通过Anthropic官网免费试用

，不过Opus模型仅限Claude Pro订阅用户使用，价格为每月20美元。Opus和Sonnet模型已通过API提供，Haiku也将很快推出API。

据悉，Claude 3系列支持即时与客户聊天、自动补全和数据提取任务。其中，Haiku是同类型模型中速度最快、性价比最高的型号：每百万token输入仅需0.25美元，输出则为1.25美元；对于arXiv网站上一篇信息和数据密度很高的论文（约1万token），Haiku仅需3秒就能读取。Claude 3系列模型也能处理各种视觉格式，包括照片、图表、图形和技术图表，能力与其他同类模型相当。此外，Claude 3还解决了此前Claude 2拒绝回答无害问题的情况；相比于Claude 2.1，Opus回答开放式问题的准确率提高了2倍，错误答案也更少了。（Anthropic）

· 

动物学

 

·

大熊猫七仔为何是棕色的？

大熊猫素来都是黑白相间，但中国秦岭地区却生活着目前世界上唯一一只棕色大熊猫——七仔，它的皮毛是棕色和白色交织在一起。近日，在一项发表于《美国科学院院刊》（PNAS）的研究中

，中国科学家找到了造成少数大熊猫棕白色皮毛的遗传机制。

研究人员基于在佛坪保护区及其周边区域的157只大熊猫的微卫星基因分型数据及圈养繁育信息，构建出棕色大熊猫“七仔”的两个家系，发现七仔的父母及后代均为黑白毛色，结合七仔和已知的丹丹家系（丹丹是中国在20世纪80年代首次发现的棕色大熊猫并于2000年去世），推断该棕色表型是由常染色体隐性遗传模式控制。然后，结合七仔、丹丹、七仔家系的四只黑色大熊猫以及其它秦岭和非秦岭地区的29只野生大熊猫，共35只熊猫个体的高深度重测序数据，研究人员确定，棕色大熊猫的BACE2基因第一外显子缺失了由25个碱基对组成的DNA片段

，这是其毛色变异的遗传基础。此外，研究人员发现，棕色大熊猫皮毛中的黑素体（负责毛发和皮肤色素沉着的细胞器）数量较少且截面积较小。未来，研究人员计划研究这些基因片段缺失是如何导致棕色大熊猫体内黑素体的大小和数量发生变化的。（

Nature news，

动物学会兽类学分会）

· 

医学

 

·

超长效艾滋病药物或将问世，仅需4个月注射一次

据葛兰素史克（GSK）官网报道，当地时间3月4日，GSK子公司ViiV Healthcare公布了其艾滋病药物卡替拉韦（cabotegravir，CAB）超长效注射剂CAB-ULA的I期临床试验结果

。数据显示，CAB-ULA仅需至少4个月注射一次，与2021年获批的卡替拉韦长效注射剂版本（CAB-LA，商品名Apretude）相比，给药间隔延长了一倍。相关研究结果公布于2024年第31届逆转录病毒和机会性感染会议（CROI 2024）。

共有70名健康成年人参与了该I期临床试验。数据显示，肌肉注射和皮下注射CAB-ULA的药物半衰期分别是肌肉注射Apretude的2倍和6倍。药代动力学模拟结果表明，每4个月或更长时间注射一次CAB-ULA可能达到与Apretude相似的药物暴露水平，可用于艾滋病治疗和人类免疫缺陷病毒（HIV）的暴露前预防（PrEP）。参与者在临床试验中对CAB-ULA的给药耐受性良好，未出现导致中止研究的不良事件。据路透社（Reuters）报道，GSK计划在今年晚些时候开展大规模临床试验，并计划于2026年推出首款预防艾滋病的超长效药物、2027年推出治疗艾滋病的超长效药物。（GSK, Reuters）

· 

医学

 

·

首次用羊水中的细胞创造出了类器官

通过从人类12次妊娠（孕期16周到34周之间）产检的羊水中收集上皮细胞，并利用单细胞测序，研究人员描述了这些细胞的性质，识别并分离出了胎儿胃肠道、肾源和肺源的上皮细胞。随后，他们培养了这些细胞，观察到它们开始增殖并自组织成三维类器官，在2周内可见。而且这些细胞会形成组织特异性原生胎儿类器官，即小肠、肾脏和肺，并显示出源组织的功能性特征。研究人员认为，这是产生胎儿类器官的一种替代方法，无需终止妊娠，解决长久以来的伦理顾虑，并可用于研究妊娠晚期阶段。不过，这还需要进一步研究验证这些发现的转化影响。

· 

行星科学

 

·

冰卫星木卫二产氧量或少于此前预期

研究人员分析了2022年9月29日“朱诺”号飞越木卫二的数据，当时它从木卫二表面上空353千米高处飞过。利用“朱诺”号上的木星极光分布实验（JADE），研究人员获得了不同拾取离子（大气中性离子与高能辐射或其他离子碰撞破裂产生的带电粒子）的丰度。根据这些数据，他们计算发现木卫二表面每秒约产生12千克的氧。而此前模型预测木卫二表面每秒产生的氧大约为5~1100千克。这表明木卫二表面的氧可能低于此前预期，因而降低木卫二宜居的可能性。

撰写：

黄雨佳、

王怡博

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.6);--weui-TAG-BACKGROUND-GREEN: rgba(6, 174, 86, .1);--weui-TAG-TEXT-BLUE: rgba(16, 174, 255, .6);--weui-TAG-BACKGROUND-BLUE: rgba(16, 174, 255, .1);--weui-TAG-TEXT-BLACK: rgba(255, 255, 255, .5);--weui-TAG-BACKGROUND-BLACK: rgba(255, 255, 255, .05)}}@media screen and (min-width:1024px){body:not(.pages_skin_pc) .wx-root[data-weui-theme=dark],body:not(.pages_skin_pc) body[data-weui-theme=dark]{--appmsgExtra-BG: #121212}}@media screen and (min-width:1024px){body:not(.pages_skin_pc)body:not(.pages_skin_pc){background:var(--weui-BG-2)}}@media screen and (min-width:1024px) and (prefers-color-scheme:dark){body:not(.pages_skin_pc) .wx-root[data-weui-mode=care]:not([data-weui-theme=light]),body:not(.pages_skin_pc) body[data-weui-mode=care]:not([data-weui-theme=light]){--weui-BG-0: #111;--weui-BG-1: #1e1e1e;--weui-BG-2: #191919;--weui-BG-3: #202020;--weui-BG-4: #404040;--weui-BG-5: #2c2c2c;--weui-FG-0: rgba(255, 255, 255, .85);--weui-FG-HALF: rgba(255, 255, 255, .65);--weui-FG-1: rgba(255, 255, 255, .55);--weui-FG-2: rgba(255, 255, 255, .35);--weui-FG-3: rgba(255, 255, 255, .1);--weui-FG-4: rgba(255, 255, 255, .15);--weui-FG-5: rgba(255, 255, 255, .1);--weui-RED: #fa5151;--weui-ORANGERED: #ff6146;--weui-ORANGE: #c87d2f;--weui-YELLOW: #cc9c00;--weui-GREEN: #74a800;--weui-LIGHTGREEN: #3eb575;--weui-BRAND: #07c160;--weui-BLUE: #10aeff;--weui-INDIGO: #1196ff;--weui-PURPLE: #8183ff;--weui-WHITE: rgba(255, 255, 255, .8);--weui-LINK: #7d90a9;--weui-TEXTGREEN: #259c5c;--weui-FG: #fff;--weui-BG: #000;--weui-TAG-TEXT-RED: rgba(250, 81, 81, .6);--weui-TAG-BACKGROUND-RED: rgba(250, 81, 81, .1);--weui-TAG-TEXT-ORANGE: rgba(250, 157, 59, .6);--weui-TAG-BACKGROUND-ORANGE: rgba(250, 157, 59, .1);--weui-TAG-TEXT-GREEN: rgba(6, 174, 86, .6);--weui-TAG-BACKGROUND-GREEN: rgba(6, 174, 86, .1);--weui-TAG-TEXT-BLUE: rgba(16, 174, 255, .6);--weui-TAG-BACKGROUND-BLUE: rgba(16, 174, 255, .1);--weui-TAG-TEXT-BLACK: rgba(255, 255, 255, .5);--weui-TAG-BACKGROUND-BLACK: rgba(255, 255, 255, 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rgba(250, 81, 81, .1);--weui-TAG-TEXT-ORANGE: rgba(250, 157, 59, .6);--weui-TAG-BACKGROUND-ORANGE: rgba(250, 157, 59, .1);--weui-TAG-TEXT-GREEN: rgba(6, 174, 86, .6);--weui-TAG-BACKGROUND-GREEN: rgba(6, 174, 86, .1);--weui-TAG-TEXT-BLUE: rgba(16, 174, 255, .6);--weui-TAG-BACKGROUND-BLUE: rgba(16, 174, 255, .1);--weui-TAG-TEXT-BLACK: rgba(255, 255, 255, .5);--weui-TAG-BACKGROUND-BLACK: rgba(255, 255, 255, .05)}}@media screen and (min-width:1024px) and (prefers-color-scheme:dark){body:not(.pages_skin_pc) .wx-root:not([data-weui-theme=light]),body:not(.pages_skin_pc) body:not([data-weui-theme=light]){--appmsgExtra-BG: #121212}}@media(prefers-color-scheme:dark){body:not([data-weui-theme=light]).my_comment_empty_data{background-color:#111}}body,.wx-root{--weui-BG-6: rgba(0, 0, 0, .05);--weui-ACTIVE-MASK: rgba(0, 0, 0, .05)}body,.wx-root{--weui-REDORANGE: #ff6146;--weui-BG-0: #ededed;--weui-BG-1: #f7f7f7;--weui-BG-2: #fff;--weui-BG-3: #f7f7f7;--weui-BG-4: #4c4c4c;--weui-BG-5: #fff;--weui-FG-0: rgba(0, 0, 0, .9);--weui-FG-HALF: rgba(0, 0, 0, .9);--weui-FG-1: rgba(0, 0, 0, .55);--weui-FG-2: rgba(0, 0, 0, .3);--weui-FG-3: rgba(0, 0, 0, .1);--weui-FG-4: rgba(0, 0, 0, .15);--weui-FG-5: rgba(0, 0, 0, .05);--weui-RED: #fa5151;--weui-ORANGERED: #ff6146;--weui-ORANGE: #fa9d3b;--weui-YELLOW: #ffc300;--weui-GREEN: #91d300;--weui-LIGHTGREEN: #95ec69;--weui-BRAND: #07c160;--weui-BLUE: #10aeff;--weui-INDIGO: #1485ee;--weui-PURPLE: #6467f0;--weui-WHITE: #fff;--weui-LINK: #576b95;--weui-TEXTGREEN: #06ae56;--weui-FG: #000;--weui-BG: #fff;--weui-TAG-TEXT-RED: rgba(250, 81, 81, .6);--weui-TAG-BACKGROUND-RED: rgba(250, 81, 81, .1);--weui-TAG-TEXT-ORANGE: #fa9d3b;--weui-TAG-BACKGROUND-ORANGE: rgba(250, 157, 59, .1);--weui-TAG-TEXT-GREEN: #06ae56;--weui-TAG-BACKGROUND-GREEN: rgba(6, 174, 86, .1);--weui-TAG-TEXT-BLUE: #10aeff;--weui-TAG-BACKGROUND-BLUE: rgba(16, 174, 255, .1);--weui-TAG-TEXT-BLACK: rgba(0, 0, 0, .5);--weui-TAG-BACKGROUND-BLACK: rgba(0, 0, 0, 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#10aeff;--weui-TAG-BACKGROUND-BLUE: rgba(16, 174, 255, .1);--weui-TAG-TEXT-BLACK: rgba(0, 0, 0, .5);--weui-TAG-BACKGROUND-BLACK: rgba(0, 0, 0, .05)}.wx-root,body{--weui-BTN-ACTIVE-MASK: rgba(0, 0, 0, .1)}.wx-root,body{--weui-BTN-DEFAULT-ACTIVE-BG: #e6e6e6}.wx-root,body{--weui-DIALOG-LINE-COLOR: rgba(0, 0, 0, .1)}.wx-root,body{--weui-BG-COLOR-ACTIVE: #ececec}@media(prefers-color-scheme:dark){.wx-root:not([data-weui-theme=light]),body:not([data-weui-theme=light]){--weui-BTN-ACTIVE-MASK: rgba(255, 255, 255, .1)}}@media(prefers-color-scheme:dark){.wx-root:not([data-weui-theme=light]),body:not([data-weui-theme=light]){--weui-BTN-DEFAULT-ACTIVE-BG: rgba(255, 255, 255, .126)}}@media(prefers-color-scheme:dark){.wx-root:not([data-weui-theme=light]),body:not([data-weui-theme=light]){--weui-DIALOG-LINE-COLOR: rgba(255, 255, 255, .1)}}@media(prefers-color-scheme:dark){.wx-root:not([data-weui-theme=light]),body:not([data-weui-theme=light]){--APPMSGCARD-BG: #1E1E1E}}@media(prefers-color-scheme:dark){.wx-root:not([data-weui-theme=light]),body:not([data-weui-theme=light]){--APPMSGCARD-LINE-BG: rgba(255, 255, 255, .07)}}@media(prefers-color-scheme:dark){.wx-root:not([data-weui-theme=light]),body:not([data-weui-theme=light]){--weui-BG-COLOR-ACTIVE: #373737}}@media(prefers-color-scheme:dark){.wx-root:not([data-weui-theme=light]),body:not([data-weui-theme=light]){--weui-BG-6: rgba(255, 255, 255, .1);--weui-ACTIVE-MASK: rgba(255, 255, 255, .1)}}@media(prefers-color-scheme:dark){.wx-root:not([data-weui-theme=light]),body:not([data-weui-theme=light]){--weui-REDORANGE: #ff6146;--weui-BG-0: #111;--weui-BG-1: #1e1e1e;--weui-BG-2: #191919;--weui-BG-3: #202020;--weui-BG-4: #404040;--weui-BG-5: #2c2c2c;--weui-FG-0: rgba(255, 255, 255, .8);--weui-FG-HALF: rgba(255, 255, 255, .6);--weui-FG-1: rgba(255, 255, 255, .5);--weui-FG-2: rgba(255, 255, 255, .3);--weui-FG-3: rgba(255, 255, 255, .1);--weui-FG-4: rgba(255, 255, 255, .15);--weui-FG-5: rgba(255, 255, 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rgba(250, 81, 81, .6);--weui-TAG-BACKGROUND-RED: rgba(250, 81, 81, .1);--weui-TAG-TEXT-ORANGE: rgba(250, 157, 59, .6);--weui-TAG-BACKGROUND-ORANGE: rgba(250, 157, 59, .1);--weui-TAG-TEXT-GREEN: rgba(6, 174, 86, .6);--weui-TAG-BACKGROUND-GREEN: rgba(6, 174, 86, .1);--weui-TAG-TEXT-BLUE: rgba(16, 174, 255, .6);--weui-TAG-BACKGROUND-BLUE: rgba(16, 174, 255, .1);--weui-TAG-TEXT-BLACK: rgba(255, 255, 255, .5);--weui-TAG-BACKGROUND-BLACK: rgba(255, 255, 255, .05)}}@media(prefers-color-scheme:dark){.wx-root:not([data-weui-theme=light]),body:not([data-weui-theme=light]){--appmsgExtra-BG: #121212}}.rich_media_content em{font-style:italic}@media screen and (min-width:1024px){body:not(.pages_skin_pc) :root{--appmsgPageGap: 20px;--appmsgPageBottomGap: 40px}}:root{--articleFontsize: 17px}:root{--sab: env(safe-area-inset-bottom)}:root{--wxBorderAvatarRatio: 3}:root{--discussPageGap: 20px}:root{--immersive-safe-bottom: env(safe-area-inset-bottom)}:root{--appmsgPageGap: 20px;--appmsgPageBottomGap: 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div.autoTypeSetting24psection > p,div.autoTypeSetting24psection > section{margin-bottom: 24px;}