NRR杂志热点综述：阿尔茨海默病治疗靶点研究

研究表明，tau蛋白的异常修饰与阿尔茨海默病相关，靶向tau蛋白的治疗策略被考虑用于预防和治疗该病。

sirtuin 2作为脑内表达最高的sirtuin，在阿尔茨海默病的发病机制中发挥复杂作用，涉及淀粉样蛋白和tau蛋白病理、微管稳定性、神经炎症、髓鞘形成、自噬和氧化应激等方面。

sirtuin 2的多种底物和不同细胞类型中的存在导致对其特定功能理解存在矛盾，需要进一步研究以明确其在不同条件下的功能，并验证其作为新型治疗靶点的可能性。

这些研究有助于开发新的阿尔茨海默病靶向治疗策略，不仅针对阿尔茨海默病，也针对其他神经退行性疾病。

为此，选择本刊学者2023-2024年发表的细胞外囊泡在神经系统疾病中作用机制的相关综述文章3篇，推荐读者阅读。

(1) SIRT2 as a potential new therapeutic target for Alzheimer's disease

作为阿尔茨海默病潜在新治疗靶点的SIRT2

Noemi Sola-Sevilla, Elena Puerta

Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Navarra, Navarra Institute for Health Research (IdiSNA), Pamplona, Spain.

引用本文：

Sola-Sevilla N, Puerta E. SIRT2 as a potential new therapeutic target for Alzheimer's disease. Neural Regen Res. 2024;19(1):124-131.

正文链接：

https://journals.lww.com/nrronline/fulltext/2024/01000/sirt2_as_a_potential_new_therapeutic_target_for.18.aspx

(2) Targeting tau in Alzheimer's disease: from mechanisms to clinical therapy

以阿尔茨海默病中的tau为靶点：从机制到临床治疗

Jinwang Ye 1, Huali Wan 2, Sihua Chen 1, Gong-Ping Liu 3 4

1 Shenzhen Key Laboratory of Marine Biotechnology and Ecology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, Guangdong Province, China.

2 Department of Laboratory Medicine, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong Province, China.

3 Co-innovation Center of Neurodegeneration, Nantong University, Nantong, Jiangsu Province, China.

4 Department of Pathophysiology, School of Basic Medicine and the Collaborative Innovation Center for Brain Science, Key Laboratory of Ministry of Education of China and Hubei Province for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.

引用本文：

Ye J, Wan H, Chen S, et al. Targeting tau in Alzheimer's disease: from mechanisms to clinical therapy. Neural Regen Res. 2024;19(7):1489-1498.

正文链接： https://journals.lww.com/nrronline/fulltext/2024/07000/targeting_tau_in_alzheimer_s_disease__from.27.aspx

(3) Genetic and epigenetic targets of natural dietary compounds as anti-Alzheimer's agents

天然膳食化合物作为抗阿尔茨海默病药物的遗传和表观遗传靶点

Willian Orlando Castillo-Ordoñez 1, Nohelia Cajas-Salazar 2, Mayra Alejandra Velasco-Reyes 2

1 Facultad de Ciencias Naturales-Exactas y de la Educación, Departamento de Biología. Universidad del Cauca, Popayán-Cauca, Colombia; Departamento de Estudios Psicológicos, Universidad Icesi, Cali, Colombia.

2 Facultad de Ciencias Naturales-Exactas y de la Educación, Departamento de Biología. Universidad del Cauca, Popayán-Cauca, Colombia.

引用本文：

Castillo-Ordoñez WO, Cajas-Salazar N, Velasco-Reyes MA. Genetic and epigenetic targets of natural dietary compounds as anti-Alzheimer's agents. Neural Regen Res. 2024;19(4):846-854.

正文链接： https://journals.lww.com/nrronline/fulltext/2024/04000/genetic_and_epigenetic_targets_of_natural_dietary.29.aspx